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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as a focus on the practical aspects of study design which include the recruitment process and consent, adhering and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and 프라그마틱 슬롯 조작 participants from various geographical areas. This type of heterogeneity which is essential for pragmatic trials to be reliable and reduce bias in results is also essential. However too much heterogeneity could cause issues with the design of the trial.

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The goal of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are usually requested by practitioners and policy makers to inform their decision making. They also provide a useful way to identify the causality between an intervention and 프라그마틱 불법 its results. However, they should not be used to replace explanatory studies.

The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the decision-making process for policy and practice. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study that includes recruitment, design, delivery of the intervention and follow-up.

There is an encouraging increase in the number pragmatic trials published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to keep in mind, however, that the majority of these studies were conducted in primary-care settings.